POLICE are appealing for witnesses after a single-vehicle crash on Thursday night which left a man seriously injured.

Just after 7.20pm on Thursday, September 6, emergency services were called to Orana Way, Lanitza, about 28 kilometres south of Grafton, after reports of a single-vehicle crash. It appeared a Mitsubishi Triton travelling south had left the road and collided head-on with a tree.

SES crews from Grafton worked for more than an hour to remove a 45-year-old man who was a passenger from the ute.

Two men were in the vehicle at the time of the crash, and were travelling south towards Coffs Harbour when the crash occurred near a wooden bridge. The vehicle crossed to the opposite side of the road and hit a number of trees.

The Westpac Life Saver Rescue Helicopter was called to the scene of the collision, and the man was airlifted from the scene to Gold Coast Base Hospital in a stable condition with serious head and spinal injuries.

The driver, a 30-year-old man, suffered relatively minor injuries and was transported by road ambulance to Coffs Harbour Hospital.

Emergency services were called to the collision at about 7.20pm on Thursday night to reports a vehicle had left the road and collided with a tree on the Orara Way, about 14km south of Grafton near the Kungala Rd intersection.

Officers from Coffs Clarence Police District and Far North Coast Crash Investigation Unit attended the scene and are investigating the circumstances and events leading up to the crash.

Anyone with information about this incident is urged to contact Crime Stoppers: 1800 333 000 or https://nsw.crimestoppers.com.au. Information is treated in strict confidence. The public is reminded not to report crime via NSW Police social media pages.